Phosphodiesterases and their inhibitors / (Record no. 21326)

MARC details
000 -LEADER
fixed length control field 06340cam a2200937Mi 4500
001 - CONTROL NUMBER
control field ocn878141373
003 - CONTROL NUMBER IDENTIFIER
control field OCoLC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20230823095532.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m o d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr cn|||||||||
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 140325t20142014gw a ob 001 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency E7B
Language of cataloging eng
Description conventions rda
-- pn
Transcribing agency E7B
Modifying agency N$T
-- YDXCP
-- DG1
-- CDX
-- EBLCP
-- IDEBK
-- SFB
-- DEBSZ
-- COO
-- DEBBG
-- OCLCQ
-- CASUM
019 ## -
-- 874321908
-- 881423826
-- 961577287
-- 962694307
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527682355
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 352768235X
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527682348
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527682341
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527332197
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527332199
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781306531955
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 1306531950
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527682376
Qualifying information (Mobi)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527682379
Qualifying information (Mobi)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 3527682368
Qualifying information (ePub)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783527682362
Qualifying information (ePub)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
Cancelled/invalid ISBN 9783527332199
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
Cancelled/invalid ISBN 9783527682379
Qualifying information (Mobi)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
Cancelled/invalid ISBN 9783527682362
Qualifying information (ePub)
029 1# - (OCLC)
OCLC library identifier CHBIS
System control number 010259738
029 1# - (OCLC)
OCLC library identifier CHVBK
System control number 325940886
029 1# - (OCLC)
OCLC library identifier DEBBG
System control number BV042795782
029 1# - (OCLC)
OCLC library identifier DEBBG
System control number BV042989481
029 1# - (OCLC)
OCLC library identifier DEBSZ
System control number 431651620
029 1# - (OCLC)
OCLC library identifier DEBSZ
System control number 449419991
029 1# - (OCLC)
OCLC library identifier GBVCP
System control number 814301746
029 1# - (OCLC)
OCLC library identifier DEBSZ
System control number 475023528
029 1# - (OCLC)
OCLC library identifier DEBBG
System control number BV043396710
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)878141373
Canceled/invalid control number (OCoLC)874321908
-- (OCoLC)881423826
-- (OCoLC)961577287
-- (OCoLC)962694307
037 ## - SOURCE OF ACQUISITION
Stock number 584446
Source of stock number/acquisition MIL
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QP609.C92
Item number .P467 2014eb
060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER
Classification number QU 136
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED
Subject category code subdivision 075000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code SCI
Subject category code subdivision 036000
Source bisacsh
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 612.01519
Edition number 23
049 ## - LOCAL HOLDINGS (OCLC)
Holding library MAIN
245 00 - TITLE STATEMENT
Title Phosphodiesterases and their inhibitors /
Statement of responsibility, etc edited by Spiros Liras and Andrew S. Bell.
264 #1 -
-- Weinheim an der Bergstrasse, Germany :
-- Wiley-VCH,
-- 2014.
264 #4 -
-- ©2014
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource (238 pages) :
Other physical details illustrations.
336 ## -
-- text
-- txt
-- rdacontent
337 ## -
-- computer
-- c
-- rdamedia
338 ## -
-- online resource
-- cr
-- rdacarrier
490 1# - SERIES STATEMENT
Series statement Methods and Principles in Medicinal Chemistry ;
Volume number/sequential designation Volume 61
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc Includes bibliographical references at the end of each chapters and index.
588 0# -
-- Print version record.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Phosphodiesterases and Their Inhibitors; Contents; List of Contributors; Preface; A Personal Foreword; 1 Introduction; 2 Toward a New Generation of PDE5 Inhibitors through Advances in Medicinal Chemistry; 2.1 Introduction; 2.2 The First-Generation Agents; 2.3 PDE5 as a Mechanism and Alternative Indications Beyond MED; 2.4 A Summary of PDE5 Chemotypes Reported Post-2010; 2.5 Second-Generation PDE5 Inhibitors from Pfizer: Pyrazolopyrimidines; 2.6 Second-Generation PDE5 Inhibitors from Pfizer: Pyridopyrazinones; 2.7 Conclusions; References.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 3 PDE4: New Structural Insights into the Regulatory Mechanism and Implications for the Design of Selective Inhibitors3.1 Introduction; 3.2 Isoforms, Domain Organization, and Splice Variants; 3.3 Structural Features of the Catalytic Site; 3.4 Regulation of PDE4 Activity; 3.5 Crystal Structure of Regulatory Domains of PDE4; 3.6 UCR2 Interaction and Selectivity; 3.7 Conclusions; References; 4 PDE4: Recent Medicinal Chemistry Strategies to Mitigate Adverse Effects; 4.1 Introduction; 4.2 Brief Summary of pan-PDE4 Inhibitors; 4.2.1 Rolipram; 4.2.2 Roflumilast; 4.2.3 Cilomilast; 4.2.4 Apremilast.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 4.3 PDE4 Strategies to Avoid Gastrointestinal Events4.3.1 Allosteric Modulation; 4.3.2 PDE4D Selectivity; 4.3.3 Pfizer; 4.3.4 Novartis; 4.3.5 Merck-Frosst; 4.3.6 GEBR-7b; 4.3.7 PDE4B Selectivity; 4.3.8 Asahi Kasei; 4.3.9 GlaxoSmithKline; 4.3.10 Pfizer; 4.3.11 Tissue Targeting; 4.3.12 Polypharmacology; 4.3.13 Olanzapine Derivatives; 4.4 Conclusions; References; 5 The Function, Enzyme Kinetics, Structural Biology, and Medicinal Chemistry of PDE10A; 5.1 Enzymology and Protein Structure; 5.2 Papaverine-Related PDE10A Inhibitors; 5.3 MP-10/PF-2545920 Class of Inhibitors.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 5.4 PF-2545920/MP-Inspired Inhibitors5.5 PF-2545920/Papaverine/Quinazoline Hybrid Series of Inhibitors; 5.6 PET Ligand Development; 5.7 Summary and Future; References; 6 The State of the Art in Selective PDE2A Inhibitor Design; 6.1 Introduction; 6.2 Selective PDE2A Inhibitors; 6.2.1 Bayer; 6.2.2 Altana AG; 6.2.3 Biotie Therapies; 6.2.4 Boehringer Ingelheim; 6.2.5 Janssen; 6.2.6 Lundbeck; 6.2.7 Merck; 6.2.8 Neuro3d; 6.2.9 Pfizer; 6.3 Methods; 6.4 Conclusions; References; 7 Crystal Structures of Phosphodiesterase 9A and Insight into Inhibitor Discovery; 7.1 Introduction.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 7.2 Subtle Asymmetry of the PDE9 Dimer in the Crystals7.3 The Structure of the PDE9 Catalytic Domain; 7.4 Interaction of Inhibitors with PDE9; 7.5 Implication on Inhibitor Selectivity; References; 8 PDEs as CNS Targets: PDE9 Inhibitors for Cognitive Deficit Diseases; 8.1 PDE9A Enzymology and Pharmacology; 8.2 Crystal Structures of PDE9A Inhibitors; 8.3 Medicinal Chemistry Efforts toward Identifying PDE9A Inhibitors for Treating Cognitive Disorders; 8.3.1 Bayer; 8.3.2 Pfizer; 8.3.3 Boehringer Ingelheim; 8.3.4 Sun Yat-Sen University, China; 8.3.5 Envivo Pharmaceuticals.
526 ## - STUDY PROGRAM INFORMATION NOTE
Department Life Sciences
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Cyclic nucleotide phosphodiesterases.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Phosphodiesterases
General subdivision Inhibitors.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Phosphodiesterases
General subdivision Inhibitors
-- Therapeutic use.
650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Cyclic nucleotide phosphodiesterases.
650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Nucleotides, Cyclic
General subdivision physiology.
650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Phosphodiesterase Inhibitors
General subdivision therapeutic use.
650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Phosphoric Diester Hydrolases
General subdivision physiology.
650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Phosphoric Diester Hydrolases.
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element MEDICAL
General subdivision Physiology.
Source of heading or term bisacsh
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element SCIENCE
General subdivision Life Sciences
-- Human Anatomy & Physiology.
Source of heading or term bisacsh
650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Phosphodiesterase Inhibitors
General subdivision chemistry.
650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Phosphodiesterase Inhibitors
General subdivision therapeutic use.
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Liras, Spiros,
Relator term editor.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Bell, Andrew S.,
Relator term editor.
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Title Phosphodiesterases and their inhibitors.
Place, publisher, and date of publication Weinheim an der Bergstrasse, Germany : Wiley-VCH, ©2014
Physical description xviii, 218 pages
Series data for related item Methods and principles in medicinal chemistry ; Volume 61
International Standard Book Number 9783527332199
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Methods and principles in medicinal chemistry ;
Volume number/sequential designation Volume 61.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1002/9783527682348">http://dx.doi.org/10.1002/9783527682348</a>
Public note Wiley Online Library
994 ## -
-- 92
-- DG1

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