TY  - BOOK
AU  - Brandon,Nicholas J.
AU  - West,Anthony R.
TI  - Cyclic-nucleotide phosphodiesterases in the central nervous system: from biology to drug discovery 
T2  - Wiley series in drug discovery and development
SN  - 9781118836323
AV  - QP370 
U1  - 612.8/2 23
PY  - 2014///]
CY  - Hoboken, New Jersey
PB  - John Wiley & Sons, Inc.
KW  - Cyclic nucleotide phosphodiesterases
KW  - Central nervous system
KW  - Physiology
KW  - Nucleotides, Cyclic
KW  - 3',5'-Cyclic-AMP Phosphodiesterases
KW  - metabolism
KW  - therapeutic use
KW  - Central Nervous System
KW  - physiology
KW  - Central Nervous System Diseases
KW  - drug therapy
KW  - Drug Discovery
KW  - MEDICAL
KW  - bisacsh
KW  - SCIENCE
KW  - Life Sciences
KW  - Human Anatomy & Physiology
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references; Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin; ls
UR  - http://dx.doi.org/10.1002/9781118836507
ER  -