TY  - BOOK
AU  - Avdeef,Alex
TI  - Absorption and drug development: solubility, permeability, and charge state 
SN  - 9781118285961
AV  - RS420 .A935 2012
U1  - 615/.19 23
PY  - 2012///
CY  - Hoboken, N.J.
PB  - John Wiley & Sons
KW  - Drugs
KW  - Metabolism
KW  - Adsorption
KW  - Drug development
KW  - Design
KW  - Medical
KW  - MEDICAL
KW  - Drug Guides
KW  - bisacsh
KW  - Nursing
KW  - Pharmacology
KW  - Pharmacy
KW  - fast
KW  - Pharmaceutical Preparations
KW  - metabolism
KW  - Administration, Oral
KW  - Cell Membrane Permeability
KW  - chemistry
KW  - Structure-Activity Relationship
KW  - Electronic books
N1  - Includes bibliographical references and index; Introduction Transport model pKa determination -- Octanol-water partitioning -- Liposome-water partitioning -- Solubility -- Permeability -- Pampa -- Permeability Caco 2/MDCK -- Permeability blood brain barrier; phr
N2  - BExplains how to perform and analyze the results of the latest physicochemical methods/b/ With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates./ This iSecond Edition/i has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:/ ulli Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group/ /lili Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier/ /lili Expanded information and methods to support pKa determination/ /lili New examples explaining the treatment of practically insoluble test compounds/ /lili Additional case studies demonstrating the use of the latest physicochemical techniques/ /lili New, revised, and expanded database tables throughout the book/ /li/ul Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book./ This iSecond Edition/i is recommended as a reference for researchers in pharmaceutical R & D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics
UR  - http://dx.doi.org/10.1002/9781118286067
ER  -