Antiviral drug strategies
De Clercq, Erik.
text
bibliography
Electronic books.
gw
2011
monographic
eng
1 online resource (xx, 406 pages) : illustrations (some color).
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de.
Outlook of the antiviral drug era, now more than 50 years after description of the first antiviral drug / Erik De Clercq -- Inhibition of HIV entry / José A. Esté -- Targeting integration beyond strand transfer: development of second-generation HIV integrase inhibitors / Arnout R.D. Voet, Marc De Maeyer, Frauke Christ, Zeger Debyser -- From saquinavir to darunavir: the impact of 10 years of medicinal chemistry on a lethal disease / Marie-Pierre de Béthune, Anik Peeters, Piet Wigerinck -- Acyclic and cyclic nucleoside phosphonates / Richard L. Mackman, Tomas Cihlar -- Helicase-primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus / Subhajit Biswas, Hugh J. Field -- Cyclophilin inhibitors / Grégoire Vuagniaux, Arnaud Hamel, Rafael Crabbé, Hervé C. Porchet, Jean-Maurice Dumont -- Alkoxyalkyl ester prodrugs of antiviral nucleoside phosphates and phosphonates / James R. Beadle, Karl Y. Hostetler -- Maribavir: a novel benzimidazole ribonucleoside for the prevention and treatment of cytomegalovirus diseases / Karen K. Biron -- Anti-HCMV compounds / Graciela Andrei, Robert Snoeck -- Lethal mutagenesis as an unconventional approach to combat HIV / Pinar Iyidogan, Karen S. Anderson -- Recent progress in the development of HCV protease inhibitors / Nagraj Mani, Bhisetti G. Rao, Tara L. Kieffer, Ann D. Kwong -- Antiviral RNAi: how to silence viruses / Karin J. von Eije, Ben Berkhout -- Neuraminidase inhibitors as anti-influenza agents / Willard Lew, Michael Z. Wang, Xiaowu Chen, James F. Rooney, Choung Kim -- From TIBO to rilpivirine: the chronicle of the discovery of the ideal nonnucleoside reverse transcriptase inhibitor / Erik De Clercq.
edited by Erik De Clercq.
Includes bibliographical references and index.
Antiviral agents
Development
Antiviral agents
Development
MEDICAL
Pharmacology
Antiviral Agents
Drug Discovery
RS431.A66 A68 2011
615.7924
QV268.5
Antiviral drug strategies
Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2011
(OCoLC)664325845
Methods and principles in medicinal chemistry ; v. 50
9783527635955
3527635955
9783527635979
3527635971
1283140918
9781283140911
10.1002/9783527635955 Wiley InterScience
http://dx.doi.org/10.1002/9783527635955
http://dx.doi.org/10.1002/9783527635955
DG1
110609
20220701010824.0
ocn729726279
eng