Statistical diagnostics for cancer : analyzing high-dimensional data /

Statistical diagnostics for cancer : analyzing high-dimensional data / edited by Frank Emmert-Streib and Matthias Dehmer. - First edition. - 1 online resource (xx, 292 pages) : illustrations (some color). - Quantitative and network biology ; volume 3 . - Quantitative and network biology ; v. 3. .

Edition statement from running title area.

Includes bibliographical references and index.

Part one: General overview. Control of type I error rates for oncology biomarker discovery with high-throughput platforms -- Overview of public cancer databases, resources, and visualization tools -- Part two: Bayesian methods. Discovery of expression signatures in chronic myeloid leukemia by Bayesian model averaging -- Bayesian ranking and selection methods in microarray studies -- Multiclass classification via Bayesian variable selection with gene expression data -- Semisupervised methods for analyzing high-dimensional genomic data -- Part three: Network-based approaches -- Colorectal cancer and its molecular subsystems: construction, interpretation, and validation -- Network medicine: disease genes in molecular networks -- Inference of gene regulatory networks in breast and ovarian cancer by integrating different genomic data -- Network-module-based approaches in cancer data analysis -- Discriminant and network analysis to study origin of cancer -- Intervention and control of gene regulatory networks: theoretical framework and application to human melanoma gene regulation -- Part four: Phenotype influence of DNA copy number aberrations. Identification of recurrent DNA copy number aberrations in tumors -- The cancer cell, its entropy, and high-dimensional molecular data.

This title discusses different methods for statistically analyzing and validating data created with high-throughput methods. It focuses on systems approaches, meaning that no single gene or protein forms the basis of the analysis but rather a more or less complex biological network.



9783527665471 3527665471 9783527665440 3527665447 9783527665457 3527665455 9781299158511 129915851X 9783527665464 3527665463

447101 MIL


Cancer--Diagnosis.
Neoplasms--genetics.
Statistics as Topic--methods.
Cancer--Diagnosis.


Electronic books.
Electronic books.

RC270 / .S73 2013eb

616.99/4075

QZ 241