Gene discovery for disease models / (Record no. 18674)

MARC details
000 -LEADER
fixed length control field 05937cam a2200709Ma 4500
001 - CONTROL NUMBER
control field ocn708563222
003 - CONTROL NUMBER IDENTIFIER
control field OCoLC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20230823095608.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m o d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr cn|||||||||
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 100706s2011 njuaf ob 001 0 eng d
010 ## - LIBRARY OF CONGRESS CONTROL NUMBER
Canceled/invalid LC control number 2010028355
040 ## - CATALOGING SOURCE
Original cataloging agency E7B
Language of cataloging eng
Description conventions pn
Transcribing agency E7B
Modifying agency CDX
-- OCLCQ
-- YDXCP
-- UIU
-- DG1
-- EBLCP
-- OCLCQ
-- N$T
-- OCLCF
-- OCLCQ
-- IDEBK
-- OCLCQ
-- COO
-- OCLCQ
-- AZK
019 ## -
-- 778206046
-- 779616846
-- 816640780
-- 860516726
-- 961562614
-- 962626156
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9780470933947
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 0470933941
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9780470933930
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 0470933933
Qualifying information (electronic bk.)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 128298974X
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781282989740
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
Cancelled/invalid ISBN 9780470499467
Qualifying information (cloth)
029 1# - (OCLC)
OCLC library identifier AU@
System control number 000049904240
029 1# - (OCLC)
OCLC library identifier DEBBG
System control number BV040495883
029 1# - (OCLC)
OCLC library identifier DKDLA
System control number 820120-katalog:000557265
029 1# - (OCLC)
OCLC library identifier HEBIS
System control number 299817601
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)708563222
Canceled/invalid control number (OCoLC)778206046
-- (OCoLC)779616846
-- (OCoLC)816640780
-- (OCoLC)860516726
-- (OCoLC)961562614
-- (OCoLC)962626156
037 ## - SOURCE OF ACQUISITION
Stock number 10.1002/9780470933947
Source of stock number/acquisition Wiley InterScience
Note http://www3.interscience.wiley.com
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number RB155
Item number .G3584 2011eb
072 #7 - SUBJECT CATEGORY CODE
Subject category code HEA
Subject category code subdivision 039060
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED
Subject category code subdivision 107000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code TCB
Source bicssc
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 616/.042
Edition number 22
049 ## - LOCAL HOLDINGS (OCLC)
Holding library MAIN
245 00 - TITLE STATEMENT
Title Gene discovery for disease models /
Statement of responsibility, etc edited by Weikuan Gu.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc Hoboken, N.J. :
Name of publisher, distributor, etc Wiley,
Date of publication, distribution, etc ©2011.
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource (xiii, 537 pages, [15] pages of plates) :
Other physical details color illustrations
336 ## -
-- text
-- txt
-- rdacontent
337 ## -
-- computer
-- c
-- rdamedia
338 ## -
-- online resource
-- cr
-- rdacarrier
347 ## -
-- data file
-- rda
380 ## -
-- Bibliography
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc Includes bibliographical references and index.
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Introduction : gene discovery-from positional cloning to genomic cloning -- High throughput gene expression analysis and the identification of expression QTLs -- DNA methylation in the pathogenesis of autoimmunity -- Ccell-based analysis with microfluidic chip -- Missing dimension : protein turnover rate measurement in gene discovery -- Bioinformatics tools for the prediction of gene function -- Determination of genomic locations of targeted genetic loci -- Mutation discovery using high throughput mutation screening technology -- Candidate screening through gene expression profile -- Candidate screening through high-density SNP array -- Gene discovery through direct genome sequencing -- Candidate screening through bioinformatics tools -- Using an integrative strategy to identify mutations -- Determination of the function of a mutant in a gene -- Confirmation of a mutation by multiple molecular approaches -- Confirmation of a mutation by microRNA -- Confirmation of function of a gene by translational approaches -- Confirmation of single nucleotide mutations -- Initial identification and confirmation of a QTL gene -- Gene discovery of crop diseases in the post genome era -- Impact of whole genome genetic element analysis on gene discovery of disease models -- Impact of whole genome protein analysis on gene discovery of disease models.
588 0# -
-- Print version record.
520 ## - SUMMARY, ETC.
Summary, etc This book provides readers with new paradigms on the mutation discovery in the postgenome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that âThe availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decadesold mouse mutants will be understood precisely at the DNA level in the near future.â? The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the postgenome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).
526 ## - STUDY PROGRAM INFORMATION NOTE
Department Biotechnology & Bioinformatics
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medical genetics.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Mutation (Biology)
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Genomics.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Genetic disorders.
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element HEALTH & FITNESS
General subdivision Diseases
-- Genetic.
Source of heading or term bisacsh
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element MEDICAL
General subdivision Genetics.
Source of heading or term bisacsh
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Genetic disorders.
Source of heading or term fast
-- (OCoLC)fst00940009
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Genomics.
Source of heading or term fast
-- (OCoLC)fst00940228
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Medical genetics.
Source of heading or term fast
-- (OCoLC)fst01014133
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Mutation (Biology)
Source of heading or term fast
-- (OCoLC)fst01031152
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Gu, Weikuan.
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Title Gene discovery for disease models.
Place, publisher, and date of publication Hoboken, N.J. : Wiley, ©2011
Record control number (DLC) 2010028355
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1002/9780470933947">http://dx.doi.org/10.1002/9780470933947</a>
Public note Wiley Online Library
994 ## -
-- 92
-- DG1

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