Diversity-oriented synthesis : (Record no. 20253)

MARC details
000 -LEADER
fixed length control field 09791cam a2200805 i 4500
001 - CONTROL NUMBER
control field ocn828911338
003 - CONTROL NUMBER IDENTIFIER
control field OCoLC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20230823095530.0
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION
fixed length control field m o d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
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008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 130227s2013 nju ob 001 0 eng
010 ## - LIBRARY OF CONGRESS CONTROL NUMBER
LC control number 2013008031
040 ## - CATALOGING SOURCE
Original cataloging agency DLC
Language of cataloging eng
Description conventions rda
-- pn
Transcribing agency DLC
Modifying agency YDX
-- DG1
-- CUS
-- EBLCP
-- N$T
-- YDXCP
-- E7B
-- OCLCF
-- IUL
-- IDEBK
-- CDX
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-- DEBSZ
-- DEBBG
-- OCLCQ
019 ## -
-- 853240174
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781118618141
Qualifying information (epub)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 1118618149
Qualifying information (epub)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781118617946
Qualifying information (pdf)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 1118617940
Qualifying information (pdf)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781118618073
Qualifying information (mobi)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 1118618076
Qualifying information (mobi)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781118618110
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 1118618114
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 1299732569
Qualifying information (ebk)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781299732568
Qualifying information (ebk)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 1118145658
Qualifying information (hardback)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9781118145654
Qualifying information (hardback)
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
Cancelled/invalid ISBN 9781118145654
Qualifying information (hardback)
029 1# - (OCLC)
OCLC library identifier AU@
System control number 000050597387
029 1# - (OCLC)
OCLC library identifier CHBIS
System control number 010026952
029 1# - (OCLC)
OCLC library identifier CHVBK
System control number 306243725
029 1# - (OCLC)
OCLC library identifier DEBBG
System control number BV041909020
029 1# - (OCLC)
OCLC library identifier DEBSZ
System control number 431442452
029 1# - (OCLC)
OCLC library identifier NLGGC
System control number 363371990
029 1# - (OCLC)
OCLC library identifier NZ1
System control number 15194722
029 1# - (OCLC)
OCLC library identifier NZ1
System control number 15341723
029 1# - (OCLC)
OCLC library identifier NZ1
System control number 16062222
029 1# - (OCLC)
OCLC library identifier DEBBG
System control number BV041829206
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)828911338
Canceled/invalid control number (OCoLC)853240174
037 ## - SOURCE OF ACQUISITION
Stock number 504507
Source of stock number/acquisition MIL
042 ## - AUTHENTICATION CODE
Authentication code pcc
050 00 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QD262
072 #7 - SUBJECT CATEGORY CODE
Subject category code SCI
Subject category code subdivision 013040
Source bisacsh
082 00 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 547/.2
Edition number 23
084 ## - OTHER CLASSIFICATION NUMBER
Classification number SCI013040
Source of number bisacsh
049 ## - LOCAL HOLDINGS (OCLC)
Holding library MAIN
245 00 - TITLE STATEMENT
Title Diversity-oriented synthesis :
Remainder of title basics and applications in organic synthesis, drug discovery, and chemical biology /
Statement of responsibility, etc edited by Andrea Trabocchi.
264 #1 -
-- Hoboken, New Jersey :
-- Wiley,
-- [2013]
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource.
336 ## -
-- text
-- txt
-- rdacontent
337 ## -
-- computer
-- c
-- rdamedia
338 ## -
-- online resource
-- cr
-- rdacarrier
520 ## - SUMMARY, ETC.
Summary, etc "This book overviews diversity-oriented synthesis (DOS), one of the leading and dynamic topics in organic chemistry and drug discovery"--
-- Provided by publisher.
504 ## - BIBLIOGRAPHY, ETC. NOTE
Bibliography, etc Includes bibliographical references and index.
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note Machine generated contents note: Foreword Stuart L. Schreiber Preface List of Contributors Abbreviations 1 The Basics of Diversity-Oriented Synthesis Kieron M.G. O'Connell, Warren R.J.D. Galloway and David R. Spring 1.1 Introduction 1.2 What is Diversity-Oriented Synthesis? 1.3 Small Molecules and Biology 1.4 Comparing DOS, TOS and Combinatorial Chemistry (Focused Library Synthesis) 1.5 Molecular Diversity 1.6 Molecular Diversity and Chemical Space 1.7 Synthetic Strategies for Creating Molecular Diversity 1.8 Reagent-Based Approaches to Diversity Generation 1.9 A Substrate-Based Approach to Skeletal Diversity Generation 1.10 Other Build/Couple/Pair Examples 1.11 Concluding Remarks 1.12 References Part I Chemical Methodology in Diversity-Oriented Synthesis 2 Strategies Applications of Multicomponent Reactions (MCRs) to Diversity-Oriented Synthesis John M. Knapp, Mark J. Kurth, Jared T. Shaw and Ashkaan Younai 2.1 Introduction 2.2 MCR Products for HTS 2.3 MCRs as Starting Points for DOS 2.4 Conclusion 2.5 References 3 Cycloaddition Reactions in Diversity-Oriented Synthesis Giovanni Muncipinto 3.1 Introduction 3.2 [4+2] Cycloaddition Reactions 3.3 Diels-Alder Reaction 3.4 Inverse Electron Demand Diels-Alder Reaction 3.5 1,3-dipolar Cycloaddition Reactions 3.6 Miscellaneous Cycloadditions 3.7 Conclusion 3.8 References 4 Phosphine Organocatalysis as the Platform for Diversity-Oriented Synthesis Ohyun Kwon and Zhiming Wang 4.1 Introduction 4.2 DOS using Phosphine Organocatalysis 4.2.1 Phosphine Organocatalysis of Allenes with Imines 4.3 Skeletal Diversity Based on a Phosphine Catalysis/Combinatorial Scaffolding Strategy 4.4 A DOS Library Based on Phosphine Organocatalysis: Biological Screening, Analogue Synthesis, and Structure-Activity Relationship Analysis 4.5 Conclusions 4.6 References 5 Domino Reactions in Library Synthesis Matthew G. LaPorte, John R. Goodell, Sammi Tsegay and Peter Wipf 5.1 Introduction 5.2 Pericyclic Domino Reactions 5.3 Anionic Domino Reactions 5.4 Transition Metal Mediated Domino Reactions 5.5 Radical Domino Reactions 5.6 Conclusions 5.7 References 6 Diversity-Oriented Synthesis of Amino Acid-Derived Scaffolds and Peptidomimetics: A Perspective Andrea Trabocchi 6.1 Introduction 6.2 Definition and Classification of Peptidomimetics 6.3 Early Combinatorial Approaches to Peptidomimetic Scaffolds 6.4 Amino Acid-Derived Scaffolds 6.5 Macrocyclic Peptidomimetic Scaffolds 6.6 Conclusion 6.7 References 7 Solid-phase Synthesis Enabling Chemical Diversity Viktor Krchňák and Nadĕ Cankařová 7.1 Introduction 7.2 Skeletal Diversity 7.3 Substrate-Based Strategy (Folding Process) 7.4 Stereochemical Diversity 7.5 Appendages Diversity 7.6 Build/Couple/Pair Strategy 7.7 Scaffold Hopping 7.8 Conclusion 7.9 References 8 Macrocycles as Templates for Diversity Generation in Drug Discovery Eric Marsault 8.1 Introduction 8.2 Challenges Associated with Macrocycles 8.3 Macrocyclic Peptides 8.4 Peptidomimetic Macrocycles 8.5 Diversity-Oriented Strategies Based on Nonpeptidic Natural Products 8.6 Conclusion 8.7 References Part II Chemical Libraries and Diversity-Oriented Synthesis 9 Diversity-Oriented Synthesis of Natural Product-Based Libraries Mark Dow, Francesco Marchetti and Adam Nelson 9.1 Introduction 9.2 Libraries Inspired by Natural Product Scaffolds 9.3 Folding Pathways in the Synthesis of Natural Product-Like Libraries 9.4 Branching Pathways in the Synthesis of Natural Product-Like Libraries 9.5 Oligomer-Based Approaches to Natural Product-Like Libraries 9.6 Summary 9.7 References 10 Chemoinformatic Characterization of the Chemical Space and Molecular Diversity of Compound Libraries Jose Luis Medina-Franco 10.1 Introduction 10.2 Concept of Chemical Space 10.3 General Aspects of Chemoinformatic Methods to Analyze the Chemical Space 10.4 Chemoinformatic-Based Analysis of Libraries Using Different Representations 10.5 Recent Trends in Computational Approaches to Characterize Compound Libraries 10.6 Concluding Remarks 10.7 References 11 DNA-Encoded Chemical Libraries Luca Mannocci 11.1 Introduction 11.2 DNA-Encoded Chemical Libraries (DECL) 11.3 Selection and Decoding 11.4 Drug Discovery by DNA-Encoded Chemical Libraries 11.5 DNA-Encoded Chemical Libraries: Prospects and Outlook 11.6 Conclusion 11.7 References PART III Screening Methods and Lead Identification 12 Experimental Approaches for Rapid Profiling and Characterization of Specific Biological Effects of Diversity-Oriented Synthesis Compounds Eduard A. Sergienko and Susanne Heynen-Genel 12.1 Introduction 12.2 Basic Principles of HTS 12.3 Common Assay Methods and Techniques 12.4 Future Perspectives 12.5 References 13 Small-Molecule Microarrays Hongyan Sun 13.1 Introduction 13.2 Chemical Library Design and Synthesis 13.3 Fabrication of SMMs 13.4 Applications of SMM 13.5 Summary and Outlook 13.6 References 14 Yeast as a Model in High-Throughput Screening of Small Molecule Libraries Duccio Cavalieri, Carlotta De Filippo and Irene Stefanini 14.1 Introduction 14.2 Chemical Genetics and S. cerevisiae 14.3 Chemical Genomics and S. cerevisiae 14.4 Conclusions: the Route of Drug Discovery with the Budding Yeast 14.5 References 15 Virtual Screening Methods Jurgen Bajorath 15.1 Introduction 15.2 Basic Virtual Screening Concepts 15.3 Molecular Similarity in Virtual Screening 15.4 Spectrum of Virtual Screening Approaches 15.5 Docking 15.6 Similarity Searching 15.7 Compound Classification 15.8 Machine Learning 15.9 Conclusions 15.10 References 16 Structure-Activity Relationship Data Analysis: Activity Landscapes and Activity Cliffs Jurgen Bajorath 16.1 Introduction 16.2 Numerical SAR Analysis Functions 16.3 Principles and Intrinsic Limitations of Activity Landscape Design 16.4 Activity Landscape Representations 16.5 Defining and Identifying Activity Cliffs 16.6 Activity Cliff Survey 16.7 Activity Cliffs and SAR Information 16.8 Concluding Remarks 16.9 References PART IV Applications in Chemical Biology and Drug Discovery 17 Diversity-Oriented Synthesis and Drug Development: Facilitating the Discovery of Novel Probes and Therapeutics Jeremy R. Duvall, Eamon Comer and Sivaraman Dandapani 17.1 Introduction 17.2 Case Study 1 -- Inhibition of Cytokine-Induced [symbol for a square]-Cell Apoptosis 17.3 Case Study 2 -- Identification of Anti-Malarials 17.4 Case Study 3 -- Targeting Protein-Protein and Protein-DNA Interactions 17.5 Conclusion 17.6 References 18 DOS-Derived Small-Molecule Probes in Chemical Biology Nicholas Hill, Lingyan Du and Qiu Wang 18.1 Introduction 18.2 DOS-Derived Small-Molecule Probes 18.3 Developing Small-Molecule Probes of Complex Biological Pathways 18.4 Expanding the Collection of Important Biological Probes 18.5 Developing Probes for Therapeutically Desirable Phenotypes 18.6 Natural Product-Inspired Small-Molecule Probes Developed from DOS and Biology-Oriented Synthesis 18.7 Summary and Outlook 18.8 References Index.
588 0# -
-- Print version record and CIP data provided by publisher.
526 ## - STUDY PROGRAM INFORMATION NOTE
Department Life Sciences
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Organic compounds
General subdivision Synthesis.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Drug development.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Biosynthesis.
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element SCIENCE
General subdivision Chemistry
-- Organic.
Source of heading or term bisacsh
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Biosynthesis.
Source of heading or term fast
-- (OCoLC)fst00832721
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Drug development.
Source of heading or term fast
-- (OCoLC)fst00898670
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Organic compounds
General subdivision Synthesis.
Source of heading or term fast
-- (OCoLC)fst01047668
655 #4 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
655 #7 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
Source of term local
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Trabocchi, Andrea.
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Title Diversity-oriented synthesis.
Place, publisher, and date of publication Hoboken, New Jersey : Wiley, [2013]
International Standard Book Number 9781118145654
Record control number (DLC) 2012048231
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1002/9781118618110">http://dx.doi.org/10.1002/9781118618110</a>
Public note Wiley Online Library
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-- 92
-- DG1

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