Thermodynamics and kinetics of drug binding / edited by György M. Keserü and David C. Swinney.

Contributor(s): Keserü, G. M [editor.] | Swinney, David Carl [editor.]Material type: TextTextSeries: Methods and principles in medicinal chemistry ; v. 65.Publisher: Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, [2015]Description: 1 online resource (xxiii, 334 pages) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9783527673049; 3527673040; 9783527673025; 3527673024; 9783527673032; 3527673032Subject(s): Drug development | Binding sites (Biochemistry) -- Thermodynamics | Pharmacokinetics | MEDICAL / Pharmacology | Binding sites (Biochemistry) -- Thermodynamics | Drug development | Pharmacokinetics | Drug Discovery | Receptors, Drug | Ligands | Thermodynamics | PharmacokineticsGenre/Form: Electronic books. | Electronic books.Additional physical formats: Print version:: Thermodynamics and kinetics of drug bindingDDC classification: 615.19 LOC classification: RM301.25 | .T44 2015ebNLM classification: W1 | QV 745Online resources: Wiley Online Library Summary: "This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors."-- Publisher's info.
List(s) this item appears in: Chemistry
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Includes bibliographical references and index.

"This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors."-- Publisher's info.

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