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Neurodegeneration : the molecular pathology of dementia and movement disorders / edited by Dennis W. Dickson.

Contributor(s): Material type: TextTextPublisher: Chichester, West Sussex : Wiley-Blackwell, 2011Edition: 2nd edDescription: 1 online resource (xvii, 477 pages) : illustrations (some color)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781444341256
  • 1444341251
  • 9781444341225
  • 1444341227
Subject(s): Genre/Form: Additional physical formats: Print version:: Neurodegeneration.DDC classification:
  • 616.8 22
LOC classification:
  • RC365 .N4527 2011eb
NLM classification:
  • WL 359
Online resources:
Contents:
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders; Contents; List of Contributors; Preface; List of Abbreviations; Part 1: Introduction: Basic Mechanisms of Neurodegeneration; 1: Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders; 2: Cell Death and Neurodegeneration; 3: Oxidative Stress and Balance in Neurodegenerative Diseases; 4: Protein Aggregation in Neurodegeneration; 5: Protein Degradation in Neurodegeneration: The Ubiquitin Pathway; 6: Genetics of Neurodegeneration; 7: Transgenic Animal Models of Proteinopathies.
Summary: Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology.�� In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries.�� Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells.
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Print version record.

Includes bibliographical references and index.

Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders; Contents; List of Contributors; Preface; List of Abbreviations; Part 1: Introduction: Basic Mechanisms of Neurodegeneration; 1: Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders; 2: Cell Death and Neurodegeneration; 3: Oxidative Stress and Balance in Neurodegenerative Diseases; 4: Protein Aggregation in Neurodegeneration; 5: Protein Degradation in Neurodegeneration: The Ubiquitin Pathway; 6: Genetics of Neurodegeneration; 7: Transgenic Animal Models of Proteinopathies.

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology.�� In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries.�� Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells.

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