Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery / edited by Nicholas J. Brandon, Anthony R. West.
Material type: TextSeries: Wiley series in drug discovery and developmentPublisher: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]Description: 1 online resource (xi, 386 pages) : illustrations (some color)Content type:- text
- computer
- online resource
- 9781118836323
- 1118836324
- 9781118836309
- 1118836308
- 9781118836538
- 1118836537
- 9781118836507
- 1118836502
- 047056668X
- 9780470566688
- Cyclic nucleotide phosphodiesterases
- Central nervous system -- Physiology
- Nucleotides, Cyclic
- 3',5'-Cyclic-AMP Phosphodiesterases -- metabolism
- 3',5'-Cyclic-AMP Phosphodiesterases -- therapeutic use
- Central Nervous System -- physiology
- Central Nervous System Diseases -- drug therapy
- Drug Discovery
- MEDICAL -- Physiology
- SCIENCE -- Life Sciences -- Human Anatomy & Physiology
- Central nervous system
- Cyclic nucleotide phosphodiesterases
- 612.8/2 23
- QP370
- QU 136
Includes bibliographical references.
Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.
Print version record and CIP data provided by publisher.
Life Sciences