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Drug transporters : molecular characterization and role in drug disposition / edited by Guofeng You, Marilyn E. Morris.

Contributor(s): Material type: TextTextSeries: Wiley series in drug discovery and developmentPublisher: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]Edition: Second editionDescription: 1 online resourceContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781118705049
  • 1118705041
  • 9781118705209
  • 1118705203
  • 9781118705308
  • 1118705300
  • 9781118704981
  • 1118704983
  • 1118489934
  • 9781118489932
Uniform titles:
  • Drug transporters (2007)
Subject(s): Genre/Form: Additional physical formats: Print version:: No titleDDC classification:
  • 571.6/4
LOC classification:
  • R857.B52
NLM classification:
  • QU 120
Online resources:
Contents:
Overview of drug transporter families -- Organic Cation and Zwitterion transporters OCT, OCTN -- Organic anion transporters OAT -- Organic anion transporting polypeptides OATP -- Mammalian peptide transporters PEPT -- The monocarboxylate transporters MCT -- The nucleoside transporters CNT, ENT -- Bile acid transporters -- Multidrug resistance protein P-glycoprotein -- Multidrug resistance-associated proteins MRP -- Breast cancer resistance protein BCRP -- Multidrug and toxin extrusion proteins MATE -- Drug transport in the liver -- Drug transport in the brain -- Drug transport in the kidney -- Drug transport in the intestine -- Drug transport in the placenta -- Experimental approaches to studying drug transport -- Transporters in drug discovery in silico approaches -- Polymorphisms of drug transporters and clinical relevance -- Diet/nutrient interactions with drug transporters -- Clinical relevance drug-drug interactions, pharmacokinetics, pharmacodynamics and toxicity -- Regulatory science perspectives on transporter studies in drug development.
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Includes bibliographical references and index.

Overview of drug transporter families -- Organic Cation and Zwitterion transporters OCT, OCTN -- Organic anion transporters OAT -- Organic anion transporting polypeptides OATP -- Mammalian peptide transporters PEPT -- The monocarboxylate transporters MCT -- The nucleoside transporters CNT, ENT -- Bile acid transporters -- Multidrug resistance protein P-glycoprotein -- Multidrug resistance-associated proteins MRP -- Breast cancer resistance protein BCRP -- Multidrug and toxin extrusion proteins MATE -- Drug transport in the liver -- Drug transport in the brain -- Drug transport in the kidney -- Drug transport in the intestine -- Drug transport in the placenta -- Experimental approaches to studying drug transport -- Transporters in drug discovery in silico approaches -- Polymorphisms of drug transporters and clinical relevance -- Diet/nutrient interactions with drug transporters -- Clinical relevance drug-drug interactions, pharmacokinetics, pharmacodynamics and toxicity -- Regulatory science perspectives on transporter studies in drug development.

Print version record and CIP data provided by publisher.

Life Sciences