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Introduction. NMR and its Place in Mechanistic Systems Biology / Ivano Bertini, Kathleen S McGreevy, Giacomo Parigi -- Structure of Biomolecules: Fundamentals / Lucia Banci, Francesca Cantini, Mirko Cevec, Hendrik R A Jonker, Senada Nozinovic, Christian Richter, Harald Schwalbe -- What Can be Learned about the Structure and Dynamics of Biomolecules from NMR / Lucio Ferella, Antonio Rosato, Paola Turano, Janez Plavec -- Role of NMR in the Study of the Structure and Dynamics of Biomolecules. Determination of Protein Structure and Dynamics / Lucio Ferella, Antonio Rosato, Paola Turano -- DNA / Janez Plavec -- RNA / Richard ⁽tefl, Vladim̕r Skleǹr -- Intrinsically Disordered Proteins / Isabella C Felli, Roberta Pierattelli, Peter Tompa -- Paramagnetic Molecules / Ivano Bertini, Claudio Luchinat, Giacomo Parigi -- Role of NMR in the Study of the Structure and Dynamics of Biomolecular Interactions. NMR Methodologies for the Analysis of Protein₆Protein Interactions / Tobias Madl, Michael Sattler -- Metal-Mediated Interactions / Simone Ciofi-Baffoni -- Protein₆Paramagnetic Protein Interactions / Peter H J Keizers, Yoshitaka Hiruma, Marcellus Ubbink -- Protein₆RNA Interactions / Vijayalaxmi Manoharan, Jose Manuel P̌rez-Cąadillas, Andres Ramos -- Protein₆DNA Interactions / Lidija Kovacic, Rolf Boelens -- NMR in Drug Discovery. High-Throughput Screening and Fragment-Based Design: General Considerations for Lead Discovery and Optimization / Maurizio Pellecchia -- Ligand-Observed NMR in Fragment-Based Approaches / Pawel Sledz, Chris Abell, Alessio Ciulli -- Interactions of Metallodrugs with DNA / Hong-Ke Liu, Peter J Sadler -- RNA as a Drug Target / Jan-Peter Ferner, Elke Duchardt Ferner, J̲rg Rinnenthal, Janina Buck, Jens W̲hnert, Harald Schwalbe -- Fluorine NMR Spectroscopy for Biochemical Screening in Drug Discovery / Claudio Dalvit -- NMR of Peptides / Johannes G Beck, Andreas O Frank, Horst Kessler -- Solid-State NMR. Biomolecular Solid-State NMR/Basics / Emeline Barbet-Massin, Guido Pintacuda -- Protein Dynamics in the Solid State / J̤zef R Lewandowski, Lyndon Emsley -- Microcrystalline Proteins ₆ An Ideal Benchmark for Methodology Development / W Trent Franks, Barth-Jan van Rossum, Benjamin Bardiaux, Enrico Ravera, Giacomo Parigi, Claudio Luchinat, Hartmut Oschkinat -- Structural Studies of Protein Fibrils by Solid-State NMR / Anja B̲ckmann, Beat H Meier -- Solid-State NMR on Membrane Proteins: Methods and Applications / A A Cukkemane, M Renault, M Baldus -- Frontiers in NMR Spectroscopy. Dynamic Nuclear Polarization / Thomas F Prisner -- C Direct Detection NMR / Isabella C Felli, Roberta Pierattelli -- Speeding up Multidimensional NMR Data Acquisition / Bernhard Brutscher, Dominique Marion, Lucio Frydman -- Metabolomics / Leonardo Tenori -- In-Cell Protein NMR Spectroscopy / David S Burz, David Cowburn, Kaushik Dutta, Alexander Shekhtman -- Structural Investigation of Cell-Free Expressed Membrane Proteins / Solmaz Sobhanifar, Sina Reckel, Frank L̲hr, Frank Bernhard, Volker D̲tsch -- Computational Aspects. Grid Computing / Antonio Rosato -- Protein₆Protein Docking with HADDOCK / Christophe Schmitz, Adrien S J Melquiond, Sjoerd J de Vries, Ezgi Karaca, Marc van Dijk, Panagiotis L Kastritis, Alexandre M J J Bonvin -- Automated Protein Structure Determination Methods / Paul Guerry, Torsten Herrmann -- NMR Structure Determination of Protein₆Ligand Complexes / Ulrich Schieborr, Sridhar Sreeramulu, Harald Schwalbe -- Small Angle X-Ray Scattering/Small Angle Neutron Scattering as Methods Complementary to NMR / M V Petoukhov, D I Svergun.

Includes bibliographical references and index.

Life Sciences