| 000 | 05300cam a2200949Ii 4500 | ||
|---|---|---|---|
| 001 | ocn795742377 | ||
| 003 | OCoLC | ||
| 005 | 20221117120749.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 120618s2012 njua ob 001 0 eng d | ||
| 040 |
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| 019 |
_a795808143 _a817082051 _a864909481 |
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| 020 |
_a9781118285961 _q(electronic bk.) |
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| 020 |
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_a9781621982265 _q(electronic bk.) |
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| 020 | _a9781280589348 | ||
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| 020 |
_a1118286030 _q(electronic bk.) |
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| 020 |
_z9781118057452 _q(cloth) |
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| 020 |
_z1118057457 _q(cloth) |
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| 020 | _z9781118286067 | ||
| 020 | _z1118286065 | ||
| 028 | 0 | 1 |
_aEB00063291 _bRecorded Books |
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| 035 |
_a(OCoLC)795742377 _z(OCoLC)795808143 _z(OCoLC)817082051 _z(OCoLC)864909481 |
||
| 050 | 4 |
_aRS420 _b.A935 2012 |
|
| 060 | 1 | 0 | _aQV 38 |
| 072 | 7 |
_aMED _x023000 _2bisacsh |
|
| 072 | 7 |
_aMED _x058170 _2bisacsh |
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| 072 | 7 |
_aMED _x071000 _2bisacsh |
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| 072 | 7 |
_aMED _x072000 _2bisacsh |
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| 082 | 0 | 4 |
_a615/.19 _223 |
| 049 | _aMAIN | ||
| 100 | 1 | _aAvdeef, Alex. | |
| 245 | 1 | 0 |
_aAbsorption and drug development : _bsolubility, permeability, and charge state / _cAlex Avdeef. |
| 264 | 1 |
_aHoboken, N.J. : _bJohn Wiley & Sons, _c�2012. |
|
| 300 |
_a1 online resource (xli, 698 pages) : _billustrations |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aIntroduction Transport model pKa determination -- Octanol-water partitioning -- Liposome-water partitioning -- Solubility -- Permeability -- Pampa -- Permeability Caco 2/MDCK -- Permeability blood brain barrier. | |
| 588 | 0 | _aPrint version record. | |
| 520 | _aBExplains how to perform and analyze the results of the latest physicochemical methods/b/ With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates./ This iSecond Edition/i has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:/ ulli Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group/ /lili Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier/ /lili Expanded information and methods to support pKa determination/ /lili New examples explaining the treatment of practically insoluble test compounds/ /lili Additional case studies demonstrating the use of the latest physicochemical techniques/ /lili New, revised, and expanded database tables throughout the book/ /li/ul Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book./ This iSecond Edition/i is recommended as a reference for researchers in pharmaceutical R & D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics. | ||
| 650 | 0 |
_aDrugs _xMetabolism. |
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| 650 | 0 | _aAdsorption. | |
| 650 | 0 | _aDrug development. | |
| 650 | 0 |
_aDrugs _xDesign. |
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| 650 | 4 | _aMedical. | |
| 650 | 7 |
_aMEDICAL _xDrug Guides. _2bisacsh |
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| 650 | 7 |
_aMEDICAL _xNursing _xPharmacology. _2bisacsh |
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| 650 | 7 |
_aMEDICAL _xPharmacology. _2bisacsh |
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| 650 | 7 |
_aMEDICAL _xPharmacy. _2bisacsh |
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| 650 | 7 |
_aAdsorption. _2fast _0(OCoLC)fst00797186 |
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| 650 | 7 |
_aDrug development. _2fast _0(OCoLC)fst00898670 |
|
| 650 | 7 |
_aDrugs _xDesign. _2fast _0(OCoLC)fst00898790 |
|
| 650 | 7 |
_aDrugs _xMetabolism. _2fast _0(OCoLC)fst00898845 |
|
| 650 | 1 | 2 |
_aPharmaceutical Preparations _xmetabolism. |
| 650 | 1 | 2 | _aAdministration, Oral. |
| 650 | 1 | 2 | _aCell Membrane Permeability. |
| 650 | 1 | 2 |
_aPharmaceutical Preparations _xchemistry. |
| 650 | 1 | 2 | _aStructure-Activity Relationship. |
| 655 | 4 | _aElectronic books. | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1002/9781118286067 |
| 994 |
_aC0 _bDG1 |
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| 999 |
_c21144 _d21103 |
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| 526 | _bphr | ||