Front Matter -- Historical Perspective on von Willebrand Disease / Erik Berntorp, Margareta Blomb̃ck -- Biosynthesis and Organization of von Willebrand Factor / Sandra L Haberichter -- Von Willebrand Factor Structure and Function / Robert R Montgomery, Sandra L Haberichter -- Modulation of von Willebrand Factor by ADAMTS13 / Jennifer Barr, David Motto -- Animal Models in von Willebrand Disease / Čcile V Denis, Olivier D Christophe, Peter J Lenting -- Classification of von Willebrand Disease / Javier Batlle, Almudena P̌rez-Rodr̕guez, Mar̕a Fernanda L̤pez-Ferǹndez -- The Epidemiology of von Willebrand Disease / Giancarlo Castaman, Francesco Rodeghiero -- Clinical Aspects of von Willebrand Disease: Bleeding History / Paula D James, Alberto Tosetto -- Laboratory Diagnosis of von Willebrand Disease: The Phenotype / Ulrich Budde, Emmanuel J Favaloro -- Molecular Diagnosis of von Willebrand Disease: The Genotype / Anne C Goodeve, Reinhard Schneppenheim -- Clinical, Laboratory, and Molecular Markers of Type 1 von Willebrand Disease / David Lillicrap, Francesco Rodeghiero, Ian Peake -- Clinical, Laboratory, and Molecular Markers of Type 2 von Willebrand Disease / Dominique Meyer, Edith Fressinaud, Claudine Mazurier -- Clinical, Laboratory, and Molecular Markers of Type 3 von Willebrand Disease / Luciano Baronciani, Augusto B Federici, Jeroen C J Eikenboom -- Pediatric Aspects of Von Willebrand Disease / Jorge Di Paola, Thomas Abshire -- Women with von Willebrand Disease / Christine A Lee, Rezan A Kadir, Peter A Kouides -- On the Use of Desmopressin in von Willebrand Disease / Stefan Lethagen, Augusto B Federici, Giancarlo Castaman -- The Use of Plasma-Derived Concentrates / Pier Mannuccio Mannucci, Massimo Franchini -- Prophylaxis in Von Willebrand Disease / Erik Berntorp -- Pathophysiology, Epidemiology, Diagnosis, and Treatment of Acquired von Willebrand Syndrome / Ulrich Budde, Augusto B Federici, Jacob H Rand -- Gene Therapy for Von Willebrand Disease / Marinee K L Chuah, Inge Petrus, Thierry VandenDriessche -- Index.

Includes bibliographical references and index.

Historical perspective on von Willebrand disease / Erik Berntorp and Margareta Blombäck -- Biosynthesis and organization of von Willebrand factor / Sandra L. Haberichter -- Von Willebrand factor structure and function / Robert R. Montgomery and Sandra L. Haberichter -- Modulation of von Willebrand factor by ADAMTS13 / Jennifer Barr and David Motto -- Animal models in von Willebrand disease / Cécile V. Denis, Olivier D. Christophe, and Peter J Lenting -- Classification of von Willebrand disease / Javier Batlle, Almudena Pérez-Rodríguez and María Fernanda López-Fernández -- The epidemiology of von Willebrand disease / Giancarlo Castaman and Francesco Rodeghiero -- Clinical aspects of von Willebrand disease : bleeding history / Paula D. James and Alberto Tosetto -- Laboratory diagnosis of von Willebrand disease : the phenotype / Ulrich Budde and Emmanuel J Favaloro -- Molecular diagnosis of von Willebrand disease : the genotype / Anne C Goodeve and Reinhard Schneppenheim -- Clinical, laboratory, and molecular markers of type 1 von Willebrand disease / David Lillicrap, Francesco Rodeghiero, and Ian Peake -- Clinical, laboratory, and molecular markers of von Willebrand disease type 2 / Dominique Meyer, Edith Fressinaud and Claudine Mazurier -- Clinical, laboratory and molecular markers of von Willebrand disease type 3 / Luciano Baronciani, Augusto B. Federici and Jeroen C.J. Eikenboom -- Pediatric aspects of von Willebrand disease / Jorge Di Paola and Thomas Abshire -- Women with von Willebrand disease / Christine A. Lee, Rezan A. Kadir, and Peter A. Kouides -- The use of desmopressin in von Willebrand disease / Stefan Lethagen, Augusto B. Federici, and Giancarlo Castaman -- The use of plasma-derived concentrates / Pier Mannuccio Mannucci, Massimo Franchini -- Prophylaxis in von Willebrand disease / Erik Berntorp -- Pathophysiology, epidemiology, diagnosis, and treatment of the acquired von Willebrand syndrome / Ulrich Budde, Augusto B. Federici, and Jacob H. Rand -- Gene therapy for von Willebrand disease / Marinee K.L. Chuah, Inge Petrus, and Thierry VandenDriessche.

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book.

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